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5-Fluoroorotic acid

  • CAS No:703-95-7 5-fluoro-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
    Molecular Structure

    Detailed Description

    Quick Details

    ProName: 5-Fluoroorotic acid, monohydrate
    CasNo: 703-95-7
    Molecular Formula: C5H3FN2O4
    Appearance: white crystalline powder
    Application: for synthesis use
    DeliveryTime: prompt
    PackAge: as per buyers
    Port: shanghai
    ProductionCapacity: 10 Metric Ton/Month
    Purity: 99%
    Storage: Room temperature
    Transportation: by air/sea
    LimitNum: 1 Kilogram
    Heavy metal: N/A

    Uses:?

    5-foa has become a valuable tool for research in the field of molecular genetics. it has been employed in the selection of resistant strains of saccharomyces cerevisiae that possess a mutant ura3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-foa is coverted to 5-fluorouridine monophosphate (5-fump) in yeast cells, which can become incorporated into rna or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-fdump). 5-fdump is a potent inhibitor of thymidylate synthase (ts), causing the cessation of dna synthesis. more recently, 5-foa has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of plasmodium falciparum. studies indicate that ts is the primary target of 5-foa in malarial parasites. the combination of 5-foa and uracil has been effective in treating mice infected with plasmodium yoelli. 5-foa may also have potential in the treatment of human malarial infections when used in combination with other agents.??

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  • 5-Fluoroorotic acid
  • 5-Fluoroorotic acid